Skip to content

Monkeypox – December 2022 Coding Tip

The American Medical Association has announced new CPT codes designed to clinically distinguish the diagnostic test and vaccinations for monkeypox. They were created to support data-driven tracking, reporting, and analysis necessary for resource planning and allocation during the public health response to the outbreak.

“The new laboratory test CPT code (87593) describes molecular diagnostic testing that detects the nucleic signature of an orthopoxvirus, including the monkeypox virus.” 1

Laboratory Test Code 87593:

  • infectious agent detection by nucleic acid (DNA or RNA)
  • orthopoxvirus (eg, monkeypox virus, cowpox virus, vaccina virus), amplified probe technique, each

The two new vaccine codes are designed to describe the two smallpox and monkeypox virus products currently available.

  • 90622 Vaccina (smallpox) virus vaccine, live, lyophilized, 0.3mL dosage, for percutaneous use
    • FDA-approved and manufactured by Sanofi Pasteur Biologics Co. for active immunization against smallpox disease for persons determined to be at high risk for smallpox infection
  • 90611 Smallpox and monkeypox vaccine, attenuated vaccinia virus, live, non-replicating, preservative free, 0.5 mL dosage, suspension, for subcutaneous use
    • FDA-approved JYNNEOS vaccine manufactured by Bavarian Nordic for prevention of smallpox and monkeypox disease in adults 18 years of age and older at high risk for smallpox or monkeypox infection

1. AMA American Medical Association

To see other coding tips, click here.